Mucoadhesive Technology
IntelGenx Mucoadhesive Technology is a solid dosage form (thin, flat tablet), which is placed in the oral cavity. Following administration, the tablet remains in close contact with the mucosal surface via programmable adhesive properties of the system. When drug permeability is high and if fast adsorption is required, the dosage form can be formulated to have a very rapid dissolution, thereby increasing the rate of drug adsorption. The controlled release system can also be adjusted to achieve a predetermined drug release pattern by increasing the residence time, promoting intimate contact with the mucosal tissue and increasing the bioadhesive properties of the dosage form. Compared to oral film, which offers immediate release, IntelGenx Mucoadhesive Technology offers either quick or controlled release as methods to control drug delivery absorption kinetics/rates and, by being placed in direct contact with the adsorption site, offers a means by which drug permeability can be increased.
Applications:
Mucosal adsorption can be a preferred method of delivery when:
- The drug can undergo a high metabolic first pass effect.
- The active ingredient is expensive and maximum delivery efficiency coupled with minimum loss is required.
- The active has poor solubility.
- Immediate release, or rapid release, is required.
- Precise plasma concentrations corresponding to therapeutic levels are required.
- Increased patient compliance is an issue, or concern.
- Immediate or Controlled Release.
Advantages of IntelGenx Mucoadhesive Technology
- Versatile residence time to enhance absorption.
- Enhanced adsorption of poorly soluble drugs.
- Easy administration, easy removal or termination and patient acceptability.
- Various sizes and shapes.
- Easy manufacturing process.
- IntelGenx patent pending.